A man with type A blood (I^A) and the autosomal dominant nail-patella syndrome (

Question

A man with type A blood (I^A) and the autosomal dominant nail-patella syndrome (Np) marries a woman with type O blood (ii) and normal nails and patellas (knee caps) [Np^+]. They have 10 children with five of each sex and all whom have their father's phenotype. These children intermarry into a population where all the people have normal nails and knee caps. Also, in this population there are 588 with type A blood and 112 with type O blood. These 10 children and their mates from the above population have 50 children. Twenty-four are type A blood with nail-patella syndrome; 16 are type A blood with normal nails and knee caps; 9 have type O blood with normal nails and knee caps, and 1 is type O blood with the nail-patella syndrome. Explain. You will need to continue the explanation on the back side of this page.

Explanation / Answer

The man is autosomal dominant with blood group A and nail patella syndrome Np whereas the female is blood group O and normal Np+

Now if all of their 10 children have nail patella syndrome so that is due to the autosomal dominant gene in their father. They have inherited the trait. And not even these children have the autosomal dominant trait of nail patella syndrome.

Now when these children will remarry into normal population , the ones who inherit this dominant trait will be affected rest offsprings will be normal.

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