The authors of the paper make a statement that \"dendritic cells provide an esse

Question

The authors of the paper make a statement that "dendritic cells provide an essential link between innate and adaptive immunity". Where, in the body, do you dendritic cells make this link between innate and adaptive in respect to Chlamydia infection? Justify your answer. Which is the first antibody isotype produced in the early stages of an infection (any infection)? Which antibody isotype is important at mucosal surfaces? What is the term used to describe the change in the antibody isotype from 7a to 7b? Why is B-cell (antibody) mediated immunity not important with a primary infection with Chlamydia? Antibodies (the molecule) against Chlamydia can neutralize the bacterium. How do antibodies neutralize the bacteria (literal answer)?

Explanation / Answer

Ans, a)Antibody M and D is produced in the early stages of infection.

b) IgA is important in mucosal surfaces.

c) Class switching recombination is the phenomenon which describes the changes in antibody isotypes. It is the process through the portion denoting the constant region of the heavy chain got changed but the variable region remains constant and thus causes the changes the isotypes of the antibody, at the same time maintaining the antigen specificity.

d) B-cell immunity is not important with a primary infection with Chlamyida because during primary infection they generates the memory cells which will potentially works during the secondary infection.

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