I found the following description on the CDC website about the new Ebola Viral D

Question

I found the following description on the CDC website about the new Ebola Viral Diseases Vaccine that is in trial: “The vaccine being used in STRIVE is rVSV-ZEBOV, or Vesicular Stomatitis Virus Zaire ebolavirus vaccine. To make this vaccine, the vesicular stomatitis virus is weakened by removing one of its genes. That gene is replaced with a single Ebola virus gene.” The vesicular stomatitis virus infects insects, cattle, horses, and pigs. This virus can lead to flu like symptoms in humans • Please describe what type of vaccine this is, whether this would illicit a natural or an artificial and a passive or an active immune response, and how likely the individual receiving this vaccine is to develop Ebola symptoms. Please justify your answers?

Explanation / Answer

RECOMBINANT VECTOR VACCINES: experimental vaccines similar to DNA vaccines, but they use an attenuated virus or bacterium to introduce DNA to cells of the body. “Vector” refers to the virus or bacterium used as the carrier. This vaccine is an example of recombinant vector vaccine where the genes will be altered and then introduced in the body using a vector. This vaccine will not generate artificially acquired passive immunity which is acquired by short-term immunization by the injection of antibodies, such as gamma globulin, that are not produced by the recipient's cells. This vaccines, will cause a natural immune response in the body without causing illness. So it will illicit a natural immune response. The individual receiving this vaccine is not likely to develop any Ebola symptoms as the body’s immune response with its set of antibodies will be triggered and ready in case of any contact with the infection.

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