33. The ds siRNA, ds miRNA or ss piRNA are ultimately used by a RISC or a RISC-l

Question

33. The ds siRNA, ds miRNA or ss piRNA are ultimately used by a RISC or a RISC-like complexes. The centrally important member of RISC that slices target mRNA is a member of the ________.
A. piwi family of proteins
B. Argonaut family of proteins
C. drosha
D. dicer

34. Which of the following RNAs would cause inhibition of mRNA translation and why?
A. siRNA, because the siRNA guide hybridizes with the target mRNA without any mismatch
B. miRNA, because the siRNA guide hybridizes with the target mRNA with some mismatch
C. piRNA, because piRNA is ssRNA, so energy-consuming denaturation of dsRNA is unnecessary

Explanation / Answer

Answer 33.

B. Argonaut Family of Proteins. The Argonaut Family of Proteins play a major role in RNA silencing proccesses.The RNA-induced Silencing Complex (RISC) constitutes of the proteins belonging to the Argonaut family and these proteins act as major catalytic components of RISC. The RISC is responsible for the silencing of the gene, a phenomena known as RNA interference (RNAi).

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