What are the potential difficulties of designing a diet to alleviate the symptom
ID: 178276 • Letter: W
Question
What are the potential difficulties of designing a diet to alleviate the symptoms of phenylketonuria?
Select the three correct statements.
a. Phenylalanine is required for protein synthesis. b. Too much phenylalanine and its derivatives cause PKU in phenylketonurics. c. One has to be cautious that the levels of phenylanine derivative, phenylpyruvic acid, do not decrease. d. Higher concentrations of tyrosine to phenylalanine can be harmful. e. Too little phenylalanine will restrict protein synthesis.Explanation / Answer
Too little phenylalanine will restrict protein synthesis
Too much of phenylalanine and its derivatives cause PKU in phenylketoneurics
Phenylalanine is required for protein synthesis.
Phenylketoneuria is a autosomal recessive disorder where dietary phenylalanine instead of getting converted to tyrosine, get converted to phenylpyruvic acid which is detected in Urine.
Designing a diet for PKU affected is a difficult task as, the diet must have a very restricted intake of phenyalanine right from infancy. This also poses a problem that levels of Phenylalanine should not reduce too much, as it is important for protein synthesis. The diet should be strict, so that very minimal Phenylalanine is supplied from outside. Along with this some medicated foods containing other essential amino acids is also given so that the patient is not deprived of other amino acids through this restrict diet.
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