13. Essential steps in the synthesis of collagen by a fibroblast (a connective t

Question

13. Essential steps in the synthesis of collagen by a fibroblast (a connective tissue cell) is shown below. What vitamin is required for reaction 1? A. Thiamine B. Niacin C Vitamin K D. Vitamin E E. Ascorbate 14. What chemical is covalently attached to the collagen protein in reaction 2? D. oligosaccharide C. Fatty acid E. ile salt A. Polypeptide B. Polynucleotide Collagen microfibril and fibres formed after cross-linking Secreted out of cell, tropocollagen formed after removal of N- and C-terminal peptides Fibroblast cytoplasm Procollagen formation nucleus O-Gal-Glc Gal-O OH OH Hydroxylation of proline NA mRNA mRNA ribosome

Explanation / Answer

13. E. Ascorbate which is (Vitamin-c) cofactor for the enzyme Prolyl hydroxilase helpful for the crosslinking of collagen subunits.

14. D. Oligo saccharides for glycosilation

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