Selective Serotonin Reuptake Inhibitors (SSRI’s) are a common pharmacological tr

Question

Selective Serotonin Reuptake Inhibitors (SSRI’s) are a common pharmacological treatment for depressive disorders. However, the mechanism for therapeutic benefit is unknown. Which of the following observations from SSRI’s imply that clinical depression is not simply the result of too little serotonin release? (Select all that apply.)

A. Clinical benefit from SSRI’s may be delayed for several days or weeks.

B. Therapeutic efficacy of SSRI’s is patient specific, some individuals are helped by SSRIs but other patients are not, even if its direct effects on reuptake are conserved.

C. Depression may also be treated with medications (MAOI’s) that prevent degradation of serotonin in the synapse.

A. Clinical benefit from SSRI’s may be delayed for several days or weeks.

B. Therapeutic efficacy of SSRI’s is patient specific, some individuals are helped by SSRIs but other patients are not, even if its direct effects on reuptake are conserved.

C. Depression may also be treated with medications (MAOI’s) that prevent degradation of serotonin in the synapse.

Explanation / Answer

Depression and related mental health conditions are caused by low serotonin levels.

SSRIs are usually the first choice medication for depression because they generally have fewer side effects than most other types of antidepressant.

SSRIs work by increasing serotonin levels in the brain.

Clinical benefit from SSRI’s may be delayed for several days or weeks.

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