based on your knowledge of transcription and translation, what could be the unde
ID: 176526 • Letter: B
Question
based on your knowledge of transcription and translation, what could be the underlying molecular defect if both mRNA and protein levels for a particular gene are higher than normal? think of several alternative explanations (possible moelcular defects if mRNA levels and protein levels are higher than normal).
based on your knowledge of transcription and translation, what could be the underlying molecular defect if mRNA levels are normal but protein levesl for a particular gene are high? think of several alternative explanations (possible molecular defects if mRNA levels are normal but protein levels are higher than normal)
Explanation / Answer
Ques-1:based on your knowledge of transcription and translation, what could be the underlying molecular defect if both mRNA and protein levels for a particular gene are higher than normal? think of several alternative explanations (possible moelcular defects if mRNA levels and protein levels are higher than normal).
Answer:
The underlying molecular defect if both mRNA and protein levels for a particular gene is due to either synonymous or nonsynonymous mutation in the gene result in substitutions, transversions, transitions of the nucleotides finally higher level foe gene expression (transcription) when RNA polymerase is going to act on the coding genome. The outcome of the mRNA is higher with more half-life to synthesize proteins higher than normal through translation. Sometimes, lack of correlation between mRNA & protein levels may lead to different “protein half-lives” finally trigger varied protein synthesis and protein degradation. Recent research has illustrated that mutations are leading to more “open reading frames (ORFs)” generation that have more ribosomal occupancy for translation as a result more protein levels in the cell
Ques-2: based on your knowledge of transcription and translation, what could be the underlying molecular defect if mRNA levels are normal but protein levesl for a particular gene are high? think of several alternative explanations (possible molecular defects if mRNA levels are normal but protein levels are higher than normal)
The underlying molecular defect if mRNA levels are normal but protein levels for a particular gene are high is depicting that the molecular defects in “splicing or post-transcriptional modification in removing introns from pre-mRNA”. Sometimes, high ORFs occupancy rates on ribosomes & more protein degradation rates may lead to high translation rate
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