Electron micrographs of a time course of HSV infection show virus particles init

Question

Electron micrographs of a time course of HSV infection show virus particles initially reacting with cell surface receptors. This is later followed by viral capsids docking with nuclear pores. Afterward, the capsids go from being full to being "empty." Which of the following best fits these observations?

A) Viral capsids are needed for the cell to become infected; only the capsids enter the nucleus.

B) The viral envelope is not required for infectivity, since the envelope does not enter the nucleus.

C) Only the genetic material of the virus is involved in the cell's infectivity, and is injected like the genome of a phage.

D) The viral envelope mediates entry into the cell, the capsid facilitates transport of the genome to the nucleus, and the genome is all that enters the nucleus.

E) The viral capsid mediates entry into the cell, and only the genomic DNA enters the nucleus, where it may or may not replicate.

B) The viral envelope is not required for infectivity, since the envelope does not enter the nucleus.

C) Only the genetic material of the virus is involved in the cell's infectivity, and is injected like the genome of a phage.

D) The viral envelope mediates entry into the cell, the capsid facilitates transport of the genome to the nucleus, and the genome is all that enters the nucleus.

E) The viral capsid mediates entry into the cell, and only the genomic DNA enters the nucleus, where it may or may not replicate.

Explanation / Answer

Ans). D) The viral envelope mediates entry into the cell, the capsid facilitates transport of the genome to the nucleus, and the genome is all that enters the nucleus.

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