1-Antigen-presenting cells make contact with T-cells via cellular junctions. Whi

Question

1-Antigen-presenting cells make contact with T-cells via cellular junctions. Which of the following is likely to mediate this junction, if liquid can pass between the cells in the extra-cellular matrix but can not pass directly from cell to cell?

a- Cadherin

b- Calnexin

c- Connexin

d- Claudin

2- Indirect junctions between the T-cell and other cells are mediated by integrin. Which extra-cellular matrix protein do cells and integrin likely bind to?

a- SRP

b- Importin

c- Fibronectin

d- Actin

a- Cadherin

b- Calnexin

c- Connexin

d- Claudin

Explanation / Answer

1. The cadherins are defined as cell-cell adhesion structures or cellular junctions that forms transcellular bridges between two cells (Endothelial cells) which are involved in the regulation of extracellular matrix components, endocytic trafficking, recycling .

So, the correct option is : a- Cadherin

2. The integrins act as transmembrane linkers that are involved in communication between cell cytoskeleton and the extracellular matrix . The integrins are majorly connected with actin filament bundles.

So, the correct option is: d- Actin

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