The figure below represents genome-wide methylation in two sets of twin (ages 3

Question

The figure below represents genome-wide methylation in two sets of twin (ages 3 and 50 years old). Using the figure, answer question 3a and 3b. Differential DNa methylation between two sets of twins, one set at age 3 (left), one set at age 50 (right) using AIMs (amplification of sites.) Different bands, corresponding to sibling specifies, changes of DNA methylation, are indicated with arrows. (Pencil A of figure of at...2005) Epigenetic difference arise during the lifetime of twins. PNAS 102:10604-1060? Copyright 2005 National Academy of Sciences. a. Which set of twins have the most similar methylation pattern? Explain. b. In both sets of twins, what would be the effect of methylation on gene expression? Why?

Explanation / Answer

1. The DNA methylation is a process of addition of methyl group to the DNA. There are divergence in the DNA methylation due to environmental factors and not genetic factors. The 3 year old twin shows more similarity in the methylation pattern as comapred to the 50 year old. Methylation process depends upon age. Aging more is responsible for the variability among twins in methylation patterns. Hypomethylated CPGs observed in centenarian DNA compared with neonates covered all genomic compartments. Also, some genes becomes hypermethylated with age which causes change in methylated patterns.

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