2a.) Which of the following statements is INCORRECT with respect to covalent mod

Question

2a.) Which of the following statements is INCORRECT with respect to covalent modification of an enzyme via phosphorylation?

A.) Phosphorylation modifies the size, shape and charge of the phosphorylated amino acid.

B.) Covalent modification via phosphorylation is irreversible.

C.) Phosphorylation results in a change in the tertiary structure of the enzyme.

D.) Phosphorylation may either decrease or increase enzyme activity.

E.) Ser, Thr or Tyr residues can be phosphorylated.

2b.) Which of the following methods of altering enzyme activity depends on the activity of protein kinases and protein phosphatases?

A.) Allostery.

B.) Feedback inhibition

C.) Covalent modification.

D.) Product inhibition.

2c.) For an enzyme that displays Michaelis-Menten kinetics what is the effect of an uncompetitive inhibitor on Vmax?

A.) It Increases

B.) It decreases

C.) It may increase or decrease

Explanation / Answer

2a.) B.) Covalent modification via phosphorylation is irreversible.

2b.)C.) Covalent modification.

2c.) B.) It decreases as the uncompetitive inhibitor binds to the enzyme substrate complex and distorts its active site it decreases the apparent Km and Vmax

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