The target of ______ , secreted by the cells of the_____ , is _____, a serum pro

Question

The target of ______ , secreted by the cells of the_____ , is _____, a serum protein secreted by the ______ . The action of  on   results in the decapeptide ______ , which then circulates to the ______ where it is converted to_____ by the action of ____ .    then elevates blood pressure by two mechanisms. It causes  of arterioles systemically thus elevating perfusion pressure, and it acts on the  causing the release of _____ , which acts on the cells of the  to increase water retention and thus increases blood volume (and pressure).

angiotensinogen                          aldosterone                         lungs
juxtaglomerular apparatus           angiotensin 1                      angiotensin 2
bradykinin                                    liver                                     Bowman's capsule
kidney                                          adrenal cortex                     adrenal medulla
proximal tubule                            distal tubule                         collecting duct
renin                                             ACE    vasodilation
vasoconstriction   

Explanation / Answer

The target of angiotensinogen , secreted by the cells of the liver , is renin , a serum protein secreted by the juxtaglomerular apparatus . The action of  on   results in the decapeptide angiotensin1 , which then circulates to the lungs where it is converted to angiotensin 2 by the action of ACE .    then elevates blood pressure by two mechanisms. It causes  of arterioles systemically thus elevating perfusion pressure, and it acts on the  causing the release of aldosterone, which acts on the cells of the  to increase water retention and thus increases blood volume (and pressure).

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