We\'re the malignant cells seen in one section derived from the patient, or were

Question

We're the malignant cells seen in one section derived from the patient, or were they a combination of the embedding process? Explain your answer.
The pathology department received a fixed paraffinembedded tissue section with a diagnosis of benign uterine fibroids. Slides were prepared for microscopic study. Only benign fibroid cells were observed on all slides, except one. A small malignant process was observed located between the fibroid and normal areas on one slide. As similar tissue was not observed on any other section, it was possible that the process was a contamination from the embedding process. To determine the origin of the malignant cells, DNA was extracted from the malignant area and compared with DNA extracted from normal tissue from the patient. The results are shown below. 120 140 160 180 200 220 240 260 280 300 320 STR analysis of suspicious tissue discovered on a paraffin section. Eight loci were tested. P. patient; T, tissue section. Were the malignant cells seen in one section derived from the patient, or were they a contaminant of the embedding process? Explain your answer.

Explanation / Answer

No, the malignant cells see in one section is not derived from the patient.

After carefully observing the given results, we can say that the results obtained from the tissue is not showing any genetic similarity with the patient. So, we can assume or confirm that the fragment of this tissue got into the sample during fixing and embedding process. The patient is having only benign fibroid cells and not malignant cells.

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