Question III. If Koba Kilminster had a severe genetic defect in the VpreB gene,

Question

Question III. If Koba Kilminster had a severe genetic defect in the VpreB gene, causing its non- expression (but the rest of Koba’s genes would be expressed normally), then [complete the sentence and assess the following statements (70-81) as either factually correct (true) or incorrect (false) in the given context]:

70. Koba’s antigen-stimulated T cells would be still able to produce interleukin-2 (IL-2).

71. Koba’s pre-B cells would be still able to produce functional chains.

72. Koba’s Ig light chain expression would be different from that in healthy persons due to enhanced allelic exclusion.

73. Koba’s b TCR chain expression would be different from that in healthy persons due to impaired allelic exclusion.

74. Koba’s pre-B cells would be unable to produce a pre-B-cell receptor.

75. Koba’s early pro-B cells would display an increased (in comparison with healthy controls) phosphorylation of the RAG-2 protein.

76. Koba would suffer from B-cell immunodeficiency.

77. Koba would not suffer from T-cell immunodeficiency.

78. Koba would suffer from bacterial infections.

79. Koba would remain healthy.

80. Koba would require strong immunosuppressive therapy in order to prevent autoimmunity.

81. Koba would suffer from B-cell immunodeficiency. not suffer from T-cell immunodeficiency. suffer from bacterial infections. require prophylactic injections of antibodies from healthy donors in order to require strong immunosuppressive therapy in order to prevent autoimmunity. require no therapy at all while maintaining full health.

Explanation / Answer

The VpreB gene encodes CD179a named polypeptide chain which is required to complete the complex structure of preB cell receptor. This cluster has also includes CD179b, Ig mu heavy chain and CD79a/CD79b heterodimer. Allelic exclusion would occur in IgH chain by VpreB gene mutation. RAG-2 protein expression would fall due to Allelic exclusion

If Koba Kilminster had a severe genetic defect in the VpreB gene, causing its non- expression (but the rest of Koba’s genes would be expressed normally), then

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