CELL BIOLOGY 1. What does clonal expansion explain? CELL BIOLOGY 1. What does cl

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CELL BIOLOGY

1. What does clonal expansion explain?

CELL BIOLOGY

1. What does clonal expansion explain?

A. How Her2 genes are amplified in certain metastatic breast cancer cells. B. How transformed 3T3 cells form foci. C. How a single human oncogene transforms mouse 3T3 cells. D. How His+Salmonella cells are generated in the Ames test. E. How cancer cells within a given lineage progressively undergo sequential adaptive mutations that confer increased proliferative capacity & survivability over time.
2. Which is the largest functional class of protein targets for anti-cancer chemotherapeutic drugs currently in use? A. Transcription factors B. Protein kinases C. Cytoskeleton proteins D. DNA synthesis proteins E. Caspases

Explanation / Answer

1. What does clonal expansion explain?

E. How cancer cells within a given lineage progressively undergo sequential adaptive mutations that confer increased proliferative capacity & survivability over time.

2. Which is the largest functional class of protein targets for anti-cancer chemotherapeutic drugs currently in use?

B. Protein kinases.

PKA represents a biomarker for tumor detection and a potential target for pharmacological treatment of drugs.Protein kinase inhibitors can be used to treat disease due to hyperactive protein kinases like mutant or over-expressed kinases in cancer.

Example-Dasatinib,Tyrosine kinases

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