Loss of BRCA activity contributes to cancer because Without BRCA, DNA polymerase

Question

Loss of BRCA activity contributes to cancer because

Without BRCA, DNA polymerase can't use its proof-reading activity

Without BRCA, cells cannot perform homology directed repair of double-stranded breaks

Without BRCA, DNA damage-sensing kinases cannot establish a cell cycle checkpoint

Without BRCA, cells can't remove oxidized bases

Without BRCA, DNA polymerase can't use its proof-reading activity

Without BRCA, cells cannot perform homology directed repair of double-stranded breaks

Without BRCA, DNA damage-sensing kinases cannot establish a cell cycle checkpoint

Without BRCA, cells can't remove oxidized bases

Explanation / Answer

Without BRCA, cell cannot perform homology directed repair of double stranded break.

Note- BRCA normally expressed in cell of breast and other tissue where ther help repair damaged DNA or destroy cell if DNA cannot be repaired.

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