1. Which of the following is not a feature of apoptosis? A. All of the answers a
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Question
1. Which of the following is not a feature of apoptosis?
A. All of the answers are a features of apoptotic cells.
B. Condensation of chromatin on the margin of the nuclear envelope.
C. Flipping of phosphatidylserine to the inner leaflet of the plasma membrane.
D. Blebbing of the plasma membrane.
E. Absence of cell lysis.
2. Which of the following is not an important trait for a successful cancer cell?
3. Which of the following genetically engineered proteins could protect cells from activating the cell-extrinsic pathway of programmed cell death when expressed in mammalian cells?
4. You identify a human cell line that is unable to express Apaf1, an adaptor protein required to form the apoptosome. You grow these cells in culture and expose them to a drug that activates the cell-intrinsic pathway of cell death by causing modest defects in microtubules. Which of the following statements best describes the morphology and physiology of the cells a few hours after exposure to the drug?
5. Tumor suppressor genes and oncogenes are implicated in carcinogenesis. However, one can predict whether a gene potentially encodes for a protein that influences carcinogenesis by examining their mutational profile. You sequence the genome of 4 cancers and identify 3 genes of interest. Which of the following genes has the best potential to an oncogene?
T345S, G366R
V254I
A.Gene A and C are potential oncogenes
6. You are working in a cancer lab on the Rb gene. Your project involves investigating how Rb acts during cancer and you need cancer cells that turned oncogenic from mutations in the Rb gene. Your boss gives you a plate of cells and asks you to figure out if they are appropriate for your project. After genomic sequencing, you found a heterozygous mutation that results in loss of function of the resulting Rb protein. Is this an appropriate cell line to use for your project?
7. Cancer can arise from mutations in DNA. In the case of breast cancer, the absence or loss of function of which gene(s) are likely to result in the inability of cancer cells to correct DNA damage?
A.Only B and D
A. The ability to stimulate angiogenesis.Explanation / Answer
Which of the following is not a feature of apoptosis?
answer) . The correct answer is option A. Absence of cell lysis is not characteristic feature of the apoptotic cell because at the final stage of apoptosis cell undergoes to lysis.
Which of the following is not an important trait for a successful cancer cell?
Answer: The ability to respond to signals that control proliferation. Cancer cell are not able to respond the proper cell cycle controlling signals so, that cell proliferation is cannot be controlled. Hence, the final answer is D.
Cancer can arise from mutations in DNA. In the case of breast cancer, the absence or loss of function of which gene(s) are likely to result in the inability of cancer cells to correct DNA damage?
Correct answer is all of the above ( option C ) because all of the gene products are very necessary for proper cell cycle regulation and each of their function depends on each other.
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