1. It requires a covalently bound derivative of pantothenic acid.. [ Choose ] bi

Question

1. It requires a covalently bound derivative of pantothenic acid..

      [ Choose ]            biotin            malic enzyme            aceyl-CoA carboxylase            malonyl-CoA            citrate            fatty acid synthase complex      

2. Product formed when acetyl-CoA is carboxylated by the additon of carbon dioxide.

      [ Choose ]            biotin            malic enzyme            aceyl-CoA carboxylase            malonyl-CoA            citrate            fatty acid synthase complex   

3. A source of NADPH

      [ Choose ]            biotin            malic enzyme            aceyl-CoA carboxylase            malonyl-CoA            citrate            fatty acid synthase complex      

For 1,2, and 3 please choose one option for each that completes the sentence.

Explanation / Answer

Ques-1:Fatty Acid Synthase Complex

Reason:

Fatty acid synthase: it is referred as a multi-enzyme complex usually required for the synthesis of fatty acids through lipogenesis. This complex is going to have a covalent binding with pantpothenic acid along with acyl carrier protein in the vicinity of its complex. This covalent bonding in the complex with pantothenic acid finally 4'-phosphopantetheine to mediate fatty acids synthesis with acetyl-CoA

Usual fatty acid synthesis from malonyl coA:

Lipogenesis of palmitic acid: It is crucial to undergo in total seven cycles of to generate 16-palmitate from the acetyl coenzyme A and seven moles of malonyl coenzyme A

Acetyl Coenzyme (2-C) A + 7 moles of malonyl (4-C) coenzyme A + 14 NADPH + 14H+---in presence of fatty acid synthase (ACP + pantothenic acid) ---> produces Palmitate + 7moles of CO2 + 8Coenzyme A + 14NADP+

Ques-2: Malonyl-CoA

Ques-3: Malic Enzyme

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