Being the compassionate and generous person that you are, you decide to donate a

Question

Being the compassionate and generous person that you are, you decide to donate a kidney to a complete stranger in need The data below are the results of several tests to determine the compatibility of you and the recipient of your kidney: Given just the above information, will the recipient accept your kidney? (yes or no) Why or why not? What is the biggest potential problem to a successful transplant using this donor and recipient? What further testing would you do? What would the potential problems be if this complete stranger needed your bone marrow instead? Why? In the context of organ transplantation, what is the increased risk associated with an individual's having received previous blood transfusions on multiple occasions? Immunosuppressive therapy is often used in treatment of autoimmune disease and prevention of transplantation. Explain the aim of the following drugs and their mechanism of action. How do the mechanism of action cause immunosuppression? Corticosteroids Cyclophosphamide Remicade Tacrolimus Simulect

Explanation / Answer

1a) The donor can donate his kidney to patient as the blood type matches and tissue match is also okay since 4 out of 6 HLA markers are same . But still one can not be sure with this much information. If the patient posses antibodies for the HLA antigens which didn't matched may cause organ rejection.

1b if the patient has any antibodies present in his serum against antigens present in donor's kidney. The antibodies will then attack the new organ and reject it. To avoid this, cross matching test is done . In this test, we determine whether the patient has antibodies against patient's donor. To determine this, patient's serum is mixed with donor's white blood cells.

1c The donor can not donate bone marrow to patient as 100% matching is mandatory for this.

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