Map Sapling Learning macmillan learning Select the statements that accurately de
ID: 172371 • Letter: M
Question
Map Sapling Learning macmillan learning Select the statements that accurately describe different ways that translocations could lead to cancer. A translocation disrupts the sequence of a gene for a protein that stimulates apoptosis. The resulting protein cannot function properly A gene for a protein that is involved in a mitotic checkpoint is placed next to the regulatory sequence of a different gene. The gene is now expressed in response to different stimuli. A new sequence is added to a proto-oncogene. The modified gene now produces a new protein that increases the rate of cell division. A translocation disrupts a gene that encodes a protein required to pass through mitotic checkpoints. The resulting protein cannot function normally A gene for a protein that stimulates apoptosis is placed next to a regulatory sequence that increases the expression of the gene.Explanation / Answer
1. A translocation disrupts sequence of the gene that stimulate apoptosis.
2. A gene for.protein involved in mitotic checkpoint is placed next to the regulatory sequence of different gene.
3. A new sequence is added to proto oncogene.
Translocation places the coding sequence of one gene in proximity to the regulatory sequence for a different gene. This type of translocation occurs in Burkitts lymphoma involving translocation between chromosome 8 and 14.
This particular translocation places the MYC proto-oncogene from chromosome 8 under the control of the powerful immunoglobin heavy chain gene (IGH) promoter on chromosome 14. The MYC protein normally signals for cell proliferation, and the translocation causes high levels of MYC overexpression in lymphoid cells, where the IGH promoter is normally active.
In other cancers, translocations fuse the coding sequences of two genes together to generate potent oncogenes.
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