When administered orally, the predator drug Rohypnol (flunitrazepam) has a bioav

Question

When administered orally, the predator drug Rohypnol (flunitrazepam) has a bioavailability F of 70%. A woman arrives unconscious in the emergency room with signs that a sexual assault may have occurred within the last hour. She weighs 120 lb, and a blood analysis reveals a Cp of flunitrazepam of 0.05 mg/L.

Estimate the size of the initial dose in mg, assuming that the concentration found is the peak concentration. Is it conceivable that a dose of this size could be administered surreptitiously in an alcoholic beverage?   

Explanation / Answer

Initial dose=Volume*Cp* WEIGHT

D= 1000*5/1000*5.44

D=27.4mg

This concentration is very high to add in alcohol beverages as it may be fatal and lead to death of the person

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