The net yield of high energy molecules form the oxidation of one mole of a gluco

Question

The net yield of high energy molecules form the oxidation of one mole of a glucose during anaerobic glycolysis is a. two moles of lactate, two moles of NADH and two moles of ATP. b. two moles of lactate and 6 moles of ATP. c. two moles of lactate and 4 moles of ATP. d. two moles of pyruvate and two moles of ATP. e. two moles of pyruvate, two moles of NADH and four moles of ATP. In the TCA cycle, carbon enters the cycle as _____ and exists as _____ with metabolic energy captured as _____, _____ and _____. a. malonate; water; NADH; ATP; NADPH b. acetyl-CoA; CO_2; NADH; ATP; NADPH c. succinyl-CoA; CO_2; ATP; NADH; NADPH d. acetyl-CoA; CO_2; ATP; NADH; FADH_2 e. malonyl-CoA; water; NADH; FADH_2; ATP. In eukaryotic cells, glycolysis occurs in the _____ and the TCA cycle reactions take place _____. a. mitochondria, cytoplasm b. cytoplasm; mitochondria c. cytoplasm; cytosol d. mitochondria; ribosomes e. cytoplasm; ribosomes. Fluoroacetate inhibits the TCA cycle. Although it does not inhibit citrate synthase, the product of this enzyme inhibits a. aconitase. b. isocitrate dehydrogenase. c. alpha-ketoglutarate dehydrogenase. d. succinate dehydrogenase. e. pyruvate dehydrogenase. Which enzymes of the TCA cycle catalyze oxidative decarboxylation reactions? a. Malate dehydrogenase and citrate synthase. b. Fumarase and succinate dehydrogenase. c. alpha-Ketoglutarate dehydrogenase and succinate dehydrongenase. d. Isocitrate dehydrogenase and alpha-ketoglutarate dehydrogenase. e. Aconitase and succinate dehydrogenase. The only reaction of the citric acid cycle that provides substrate-level phosphorylation is catalyzed by

Explanation / Answer

17.Anaerobic glycolysis of glucose results in the formation of lactate. One mole of glucose is hydrolyzed to 2 moles of lactate and during this process 2 moles of ATP is formed. So none of the options are correct.

18. In TCA cycle carbon enters the cycle as acetyl-CoA and exists as CO2 with the production of metabolic energy captured as ATP, NADH, and FADH2. So the correct option is option d.

19. In eukaryotes glycolysis occurs in the cytoplasm and TCA cycle occurs in the mitochondria as the enzymes required for the same are present in the cytoplasm and mitochondria respectively. So the correct option is option b.

20. Fluoroacetate combines with coenzyme A and forms fluoroacetyl CoA. Fluoroacetyl CoA produces fluorocitrate by reacting with citrate synthase and fluorocitrate is an inhibitor of aconitase enzyme that catalyzes the conversion of citrate to isocitrate in TCA cycle. So the correct option is option a.

21. Isocitrate dehydrogenase and alpha-ketoglutarate dehydrogenase enzymes catalyze oxidative decarboxylation reactions in TCA cycle. Isocitrate dehydrogenase catalyzes the oxidative decarboxylation of isocitrate to alpha-ketoglutarate while alpha-ketoglutarate dehydrogenase catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl CoA. So the correct option is option d.

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