Which of the following processes is an element of the dissolution and disassembl

Question

Which of the following processes is an element of the dissolution and disassembly of the nuclear envelope at the end of prophase? Nuclear pore complexes are disassembled as interactions between the nucleoporin complexes arc disrupted and the proteins dissociate into the surrounding medium. The nuclear lamina is disassembled by depolymerization of the lamin filaments. Nuclear membrane integrity is disrupted mechanically as holes are torn into the nuclear envelope by cytoplasmic dynein molecules associated with the outer nuclear membrane. All of these are correct answers.

Explanation / Answer

Ans:

The following processes is an element of the dissolution and disassembly of the nuclear envelope at the end of prophase:

- Nuclear pore complexes are disassembled as interactions between the nucleoporin complexes are disrupted and the proteins dissolve into the surronding medium.

- The nuclear lamina is disassembled by depolymerization of the lamin filaments.

- Nuclear membrane integrity is disrupted mechanically as holes are torn into the nuclear envelope by cytoplasmic dynein molecules associated with the outer nuclear membrane.

- All of these are correct answers.

Explanation:

- The three major components of the nuclear envelope: the nuclear pore complexes, nuclear lamina and nuclear membranes are disassembled in seperate process at the end of prophase.

- All of these process are thought to be initiated by phosphorylation of key substrates by mitotic kinases, particularly cyclin B-Cdk1.

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