Please post the following: 1. Two-three sentences summarizing the main points of

Question

Please post the following: 1. Two-three sentences summarizing the main points of the paper; 2. In three-four sentences describe a technique used in the paper, why it was used and what it revealed; 3. At least one paragraph in which you provide a detailed description of a discussion point (an interesting feature; a question raised by the article that you attempt to answer). 4. A paragraph in which you critique the review article, that is, what would you change in it? Focus on content not style.

article: http://www.nature.com/nature/journal/v543/n7643/pdf/nature21407.pdf

Explanation / Answer

Strategies used within the article
Through experimentally stretching epithelia, we discover that mechanical stretch itself swiftly stimulates mobile department via activation of the Piezo1 channel. To stimulate cellular department, stretch triggers cells which might be paused in early G2 section to set off calcium-dependent phosphorylation of ERK1/2, so by means of trigerring the cyclin B transcription this is vital to power cells into mitosis. even though both epithelial mobile department and cell extrusion require Piezo1 at the steady nation, the type of mechanical pressure controls the final results: stretch induces cellular division, while crowding induces extrusion.

Quetions raised inside the article.
How does the range of dying cells fit the ones dividing to keep regular numbers? while epithelial cells emerge as too crowded, they activate the stretch-activated channel Piezo1 to trigger extrusion of cells that later die. however, it's miles unclear how epithelial mobile department is managed to balance cellular death at the constant state. here we display that mammalian epithelial cellular department happens in regions of low cell density where cells are stretched.
How Piezo1-based calcium transients spark off opposing methods may additionally rely uponwhere in and how Piezo1 is activated, as it accumulates in exceptional subcellular websites with increasing mobile density. The cells divide in sparse epithelial regions wherein Piezo1 localizes to the plasma membrane and cytoplasm, while in dense areas in which cells extrude, it forms big cytoplasmic aggregates.

Summary
in spite of appearing as a barrier for the organs they enclose, epithelial cells turn over at a number of the fastest quotes within the frame.
but, epithelial mobile division have to be tightly related to cellular demise to preserve barrier feature and save you tumour formation.
The mechanical stretch itself unexpectedly stimulates mobile department via activation of the Piezo1 channel. Stretch triggers cells which can be paused in early G2 phase to set off calcium-dependent phosphorylation of ERK1/2.
because each mechanical crowding and stretch are senced via Piezo1, it is able to act as a homeostatic sensor to control epithelial cell numbers, triggering extrusion and apoptosis in crowded regions and cell department in sparse regions.

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