To shut down a signalling pathway based on a receptor tyrosine kinase, an monocl

Question

To shut down a signalling pathway based on a receptor tyrosine kinase, an monoclonal antibody that targets the hormone receptor on the outside of the cell would be a viable therapeutic approach if: SELECT ALL TAHT APPLY

A. The antibody binding prevents receptor dimerization and thus keeps the intracellular kinase domains from phosphorylating each other

B. The antibody is administered such that it can easily reach the cell (for example through an IV injection)

C. The antibody bound strongly to albumin, preventing it from reaching its target

Explanation / Answer

A. The antibody binding prevents receptor dimerization and thus keeps the intracellular kinase domains from phosphorylating each other

B. The antibody is administered such that it can easily reach the cell (for example through an IV injection)

explination)

Phosphorylation has to do with interferance in working of RTK signalling .... and intravenous administration makes it a viable therapeutic approach.

Hope it helps ....feel free to discuss and comment regards ....

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