In neuronal cells, the enzyme calcineurin becomes phosphorylated in response to

Question

In neuronal cells, the enzyme calcineurin becomes phosphorylated in response to binding of the neurotransmitter glutamate to the postsynaptic membrane. Using the non-hydrolyzable GTP analog GTP-S, you find that when neuronal cells are treated with this compound phosphorylation of calcineurin occurs, but when glutamate is washed away from the cells the phosphorylation reaction continues for a prolonged period of time. Provide an explanation for these observations.

I'm slightly confused about this problem and the only explanation that I can say is that by using the non-hydrolyzable GTP analog GTP-S, it causes the enzyme to be not constitiuitly active. Other than that I really have no idea on what the question is asking and I can't find any information regarding this in the textbook.

Explanation / Answer

the compound phosphorylation that causes the reactions is treated with GTPSX and carbonic acid. This induces the calcineurin to become crystallized and merges with the phsophorylation reaction.

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