Use the terms below to fill in the blanks. Acetylcholine binds to (adrenergic ch
ID: 166809 • Letter: U
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Use the terms below to fill in the blanks. Acetylcholine binds to (adrenergic cholinergic receptors and normally (increases/decreases) the heart rate by activating blocking) (nicotinic/muscarinic) receptors which are also (ionotropic/metabotropic) On the heart, norepinephrine binds to (adrenergic/cholinergic) receptors and (increases/decreases) the heart rate by (activating/blocking) (ionotropic/metabotropic) receptor. Atropine normally (increases/decreases) the heart rate by (activating/blocking) a)n) (cholinergic/adrenergic) receptor which is also (nicotinic/muscarinic) and (ionotropic/metabotropic)Explanation / Answer
A) Acetylcholine binds to cholinergic receptors and decreases heart rate by activating muscarinic receptor which is also metabotropic.
As acetylcholine is neurotransmitter which is released by presynaptic nerve into synaptic celft which is further act on the receptor I.e. act on the muscuranic receptor of the postsynaptic nerve which causes stimulation of muscles, stimulation of exocrine glands which result in the increse in sectaretion of saliva and it also act on CNS to regulate slewp, wakefulness and memory.
Bolck and mimicking action of Acetylcholine has many uses in medicine such as drug acting on the Acetylcholine receptors like act on muscuranic rwcwptor and mimic the action like Acetylcholine and cause decrease in heart by acting on peripheral nervs I.e. act on ANS.
There are mainly four types of receeptor which play role in change in body at molecular level by activating or by blocking such receptors.
Four typea of receptor inculde 1) muscuranic 2) nicotinic 3) G-protein coupled rwceptor and ion gated ligand channel receptor.
Acetylcholine acts on muscuranic receptor and responsible for decrease in heart rate by acting on peripheral nervs I.e vague nerve.
B) On the heart norepinephrine binds to adrenergic rwcwptor and increase heart rate by blocking metabotropic receptor.
Norepinephrine is neurotransmitter which is also called noradrenaline which is classified as sympathomimetic action.
It function as neurotransmitter and binds to post noradreneric rwceptor and activate them which is responsible for increasing heart rate and also it increase blood pressure.
C) Atropine normally increase heart rate by blocking cholinergic receptor which is also muscuranic and metabotropic.
Atropine act as antagonist (which reduce the level of receptor activities) and block the activities of muacuranic receptor located at postsynaptic receptor and which is rwsult into decrease in acetylcholine level and causes increase in heart rate.
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