For a biochemistry review: 6. (ldoA2S), derived from idose, is glycosaminoglycan

Question

For a biochemistry review:
6. (ldoA2S), derived from idose, is glycosaminoglycan of the protein? which lduronic acid the containing hexose (alduronic acid) found in heparin. Is there a problem? CH20so3 O. H OH H OSO3 H NHOSO3 L-lduronate- N-Sulfo-D-glucosamine- 2-sulfate 6-sulfate Heparin s..- If a protein binds to sulfated regions of a about these statements is most likely to be false a. This protein will contain R and K residues. b. Overall, this protein will be positively charged. c. This protein will have a pl that is relatively high. d. None of these are false. e. All of these are false 7. Antithrombin binds to sulfated domains in heparan sulfate. What amino acids do you expect to be associated with this binding? a. K b. F c. E d. Y e. None of these.

Explanation / Answer

1. in the structure in the second ring (N-sulfo-D glucosamine-6-Sufate) in place of NHOSO3 it should be NHSO3. it valacis are fulfilled by this.

2. overall charge will be positive is incorrect statement beacuse the positively changed amino acid binding to the sulfate regions of the heparin will neutralize the negative charge.

3.  The binding sites in the protein always contain basic amino acids (Lys and Arg) whose positive charges may interact with the negatively charged sulfates therefore the most likely aminoacid binds to the heparin will be lysine (K).

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