CASE STUDY 2 John was a member of a university Alumni team that travelled to Sou

Question

CASE STUDY 2

John was a member of a university Alumni team that travelled to South America for a medical mission. Unfortunately he was infected with a new strain of gramnegative organism. Five days later, he was treated with antibiotics to reduce the infection.

Question 10. The receptors that are involved in the interaction on the immune system with this organism are?

a. NOD

.b. TLR

c. C3

d. C3b

Question11. The cells most likely to be involved in the early phase of the infection?

a. Macrophages

b. Epithelial cells

c. B cells

d. Both A and C

CASE STUDY 1

* Dottie Oblonski was doing well in her first year of university when she developed a cough and diarrhea. She felt very tired an achy and went to bed early in her dormitory room. The next morning she woke early with severe headache, stiff neck and high fever. Her roommate called the ambulance and she was rushed to the hospital. A check of her blood pressure showed that it was very low (70/40). Blood cultures were grown and found to be positive for Neisseria meningitides (meningococcus). The cerebrospinal fluid test was clear of any organisms, but the had a much high number of white blood cells. Her blood white-cell count was determined and had 90% neutrophils and low number of lymphocytes. Intravenous antibiotic therapy was administered and she improved over the next 48 hours.

Question1. Which of the following events are most likely to occur in the first 8 hours of the medical episode?

a. Pathogens are engulfed by macrophages

b. Pathogen infected cells are killed by natural killer cells

c. T cells are recruited to engulf infect cells

d. Both A and B are correct

e. Both B and C are correct

Question 2. During the first 8 hours the cytokines produced by phagocytes may lead to systemic effects such as fever.

a. The above statement is true

b. The above statement is incorrect

Question3. Which other event is most like to occur during this 8-hour period?

a. Mass proliferation of T cells

b. Mass proliferation of T cells

c. Production of antimicrobial peptides

d. Rapid generation of antibodies

Question4. Which of the following or tissue is involved in the early response?

a. Kidney

b. Liver

c. Lungs

d. Heart

Question5. Which of the following molecules are involved in the response?

a. TLR

b. PAMPs

c. CD3

d. CD4

e. Both A and B

Question 6. Which of the following statement is correct regarding this early phase episode?

a. Responses point to the importance of the adaptive immune system in quickly suppressing the onset of the illness

b. The innate system is engaged utilizing phagocytosis, the complement system, and opsoniztion

c. Chronic infections can be quickly rectified by the involvement of phagocytes

d. Both A and B are correct

Question7. The low blood pressure is not typical in a person with this type of infection

a. The above assumption is correct

b. The above assumption is incorrect

c. No opinion can be drawn from this statement

d. Blood pressure is irrelevant in an infection

Question8. Follow up testing indicated that Dottie was deficient in complement component 8. What is the possible consequence of this diagnosis

a. Interferon production will be impaired

b. B cell function will be impaired

c. The proper function of the membrane attack complex will be affected

d. The toll-like receptor will not transduce signals

Question 9. Dottie’s siblings were asked to take part in genetic testing to see if they were also affected. Results from the test showed that the elder sibling (Martha) has a deficiency in properdin. Which of the following is a possible effect of this diagnosis?

a. The classical properdin production would be affected

b. The Alternate properdin pathway would be affected

c. The C1q/antibody interaction would be affected

d. There would be a significant elevation in the level of C3 convertase

Explanation / Answer

Question 10:

Ans:

The receptors that are involved in the interaction on the immune system with a new strain of gram negative organism are:TLR

Explanation:

-TLR means Toll-like receptor.

-TLRs are a class of proteins that play key role in the innate immune system.

-They are usually expressed in macrophages and dentritic cells, that recognize structually conserved molecules derived from microbes.

-Activation of a receptor stimulates release of cytokines and other chemical signals that are a part of innate immunity.

Related Questions

Navigate

• Browse (All)
• Browse C
• Subjects

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.