1) A) Below is a pedigree for an uncle-niece mating (popular in some polygamist
ID: 166033 • Letter: 1
Question
1) A) Below is a pedigree for an uncle-niece mating (popular in some polygamist communities. Use the B) Suppose a rare recessive disorder occurs in one out of 10,000 newborns in the general population. Approximately how many affected individuals per 10,000 would you expect in the offspring of uncle-niece (or aunt-nephew) matings? 2 Choose the correct answer from the list below, and explain your reasoning. The major genetic effect of inbreeding is to i. increase the number of loci at which the offspring are homozygous ii. increase the number of loci at which the offspring are heterozygous iii. increase the average number of recessive alleles in the offspring iv. The first and third choices are both correct v. The second and third choices are both correct 3) By what fraction would you expect heterozygosity to decline over 25 generations in a population with effective size (N)of 50 and actual size of 100? 4) Aside from inbreeding depression, what is another adverse genetic consequence ofsmall population size? OYour answer should be something that could apply, at least in principle, to an asexual or haploid species). 5) A) How old is a rock in which the ratio of argon-40 to potassium-40 is 3:1? B) Based on your answer to (A), what kind of fossil life, if any, would you expect to find in such a rock'Explanation / Answer
qestion 1
Inbreeding coefficient for uncle niece mating =1/8=0.125 ---for one allele
Inbreeding coefficient for four allele =0.125 x 0.125 *0.125 *0.125 = 0.00024414062 ------------answer
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Suppose a rare disorder occurs in one out of 10000 new born in the general population approximately how many affected individual’s per 10000 would be you expect in the offspring of uncle niece (or aunt –nephew ) mating
FREQUENCY OF DISORDER = (1/10000* .125) =0.0000125
=ZERO----------ANSWER
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Q2
Answer : option I ---------correct
Because of inbreeding, there will be INCREASE HOMOZYGOSITY OF RECESSIVE ALLELES.
The occurrence of metabolic issue, basic variations from the norm and acquired ailment conditions, created by hurtful latent qualities, expands taking after inbreeding. Execution in a few characters, especially those worried with generation and survival, decays taking after the mating of close relatives. This is known as inbreeding misery. These impacts are for the most part because of an expansion in the recurrence of homozygous genotypes (AA and aa) to the detriment of heterozygotes (Aa), which is brought about by inbreeding. It is just destructive, in any case, when the predominance is directional, which implies that the undesirable individual from a couple of qualities is normally latent. At the point when a high extent of these destructive qualities are available in the heterozygous state (Aa) the creature is shielded from their crippling impacts by the predominance of the ordinary quality; yet when a portion of the heterozygotes are supplanted by homozygous recessives (aa), taking after inbreeding, their unsafe impacts get to be distinctly show. Different sorts of quality activity are now and again in charge of inbreeding harm, yet are thought to be less imperative. These are: overdominance, epistatic communication and the general level of heterozygosity.
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