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Multiple answers may apply 1. Select all that are TRUE for pluripotent hematopoi

ID: 165392 • Letter: M

Question

Multiple answers may apply

1. Select all that are TRUE for pluripotent hematopoietic stem cells:

they are found primarily in the bone marrow.

another name for them is uncommitted stem cells

they eventually differentiate in to lymphocytes

they eventually differentiate in to megakaryocytes

they eventually differentiate in to erythrocytes.

2. Which of the following is secreted due to hypoxic conditions?

erythropoietin (EPO)

colony-stimulating factors (CSF)s

thrombopoietin (TPO)

platelet-activating factor (PAF)

3. Platelet factors _________________________. [select all that apply]

increase vasoconstriction of the damaged blood vessel.

cause more platelets to adhere.

initiate the formation of the fibrin mesh.

are released by platelets when they adhere to collagen.

4. Which of the following are involved in coagulation? [select all that apply]

Ca2+

collagen

tissue factor

tissue plasminogen activator (tPA)

prothrombin

antithrombin III

5. What would you expect to happen to the coagulation cascade if an individual was unable to produce prothrombin?

decrease in fibrin

decrease in active XII

decrease in active XI

increase in fibrinogen

increase in inactive VII

increase in tissue factor (III)

Multiple answers may apply

1. Select all that are TRUE for pluripotent hematopoietic stem cells:

they are found primarily in the bone marrow.

another name for them is uncommitted stem cells

they eventually differentiate in to lymphocytes

they eventually differentiate in to megakaryocytes

they eventually differentiate in to erythrocytes.

Explanation / Answer

1Ans:

pluripotent hematopoietic stem cells are found primarily in the bone marrow. these stem cells are uncommitted cells and they eventually differentiate into lymphocytes, megakaryoctes and erythrocytes.

so all the statements are true.

2 Ans:

Hypoxic condition increased erythropoietin (EPO) production due to tissue hypoxia.

so the answer is erythropoietin (EPO)

3 Ans:

Haemostasis is the process in which bleeding is stopped. it involves 3 steps

vasoconstriction-narrowing of damaged blood vessels to reduce blood loss.this is caused by contraction of the smooth muscle in the wall of the vessels.

Activation of platelets-they are stick to each other and to collagen fibres in the broken walls of blood vessels, forming a platelet plug that temporarily blocks blood flow.

Formation of a blood clot-the clot contains fibres that trap the platelests.

so all the statements are true.

4 Ans:

Coagulation factors are:

Ca2+, collagen, tissue factor and prothrombin.

5Ans:

The coagulation cascade if an individual was unable to produce prothrombin, it will decrease in fibrin.