The primary amino acid sequence of collagen isGly-X-Pro/Hydroxypro, where the X

Question

The primary amino acid sequence of collagen isGly-X-Pro/Hydroxypro, where the X residue can be any residue, butit is frequently hydroxylated lysine or proline residues. Why wouldyou NOT expect this sequence to form a classical alpha-helix? Any thoughts guys? Any would help please!!! The primary amino acid sequence of collagen isGly-X-Pro/Hydroxypro, where the X residue can be any residue, butit is frequently hydroxylated lysine or proline residues. Why wouldyou NOT expect this sequence to form a classical alpha-helix? Any thoughts guys? Any would help please!!!

Explanation / Answer

In normal alpha helix, the cyclical side chain of proline result insteric hindrance that will lose its conformational entropy uponfolding. In collagen, the proline and lysine are hydroxylated. This increasethe conformationla stability of collagen, thus it can fits well tothe collagen structure. Hope this helps!

Related Questions

Navigate

• Browse (All)
• Browse T
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.