Which of the following defects is most likely to be found in yeast cells with a

Question

Which of the following defects is most likely to be found in yeast cells with a dramatically increased rate of genomic mutation per cell cycle ?

A Activation of a G1/S DNA damage checkpoint in the absence of DNA damage.

B Activation of a G1 restriction point checkpoint despite adequate cell size and nutrient supply.

C A nonsense mutation within a DNA replication polymerase.

D An inactivating mutation within a gene encoding an essential component of the unreplicated DNA checkpoint.

E Activation of a G2/M DNA damage checkpoint in the absence of DNA damage.

Explanation / Answer

A nonsense mutation is a mutation in which codon which codes for any amino acids mutated into the stop codon. As a result of it, their will premature termination of translation which leads to the expression of the non-functional protein.

DNA polymerase is the enzyme which replicated the genomic DNA into two daughter DNA. if there is any non-sense mutation in the DNA polymerase this will lead to the catastrophic effect on the cells.

So the answer will be option C A nonsense mutation within a DNA replication polymerase. if this option is not correct that option D An inactivating mutation within a gene encoding an essential component of the unreplicated DNA checkpoint might be true.

Mutation in the gene encoding an essential component of the unreplicated DNA checkpoint will hamper the cells from checking whether the replication is successful or not if yes then the cell can enter into mitosis. But due to mutation, there won't be any checkpoint which leads to the random distribution of chromosomes during mitosis which ultimately leads to cell death.

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