16) (6 points A man comes to you because of a disease that runs in his family. T
ID: 163188 • Letter: 1
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16) (6 points A man comes to you because of a disease that runs in his family. Those with the disease are prone to fatigue and muscle weakness. His mother had a mild case, and all of his siblings are affected, but to different degrees. His father is unaffected. Your patient has a more severe case He's worried that he might pass on the disease if he had biological children, and he wants to know if he should use a sperm donor. a) What kind of disease is this? How could you tell? b) Does your patient have to worry about passing it on? Why? 17) (9 points) the following segments: Two nonhomologous chromosomes have A BCD EEG R S T U V W X Draw chromosomes that would result from the following chromosome rearrangements a. Reciprocal translocation of CD and TU b. Translocation of EFG to the other chromosome c. Robertsonian translocationExplanation / Answer
16. A. The disease is an autosomal dominant disease, because all the progeny affected with the disease even though one of their parent not possess disease.
B. Yes. Patient need to worry of passing of this disease to the next generation, from his sperms. Because as the disease is autosomal, and sperm contain one set of the autosomes, the disease will pass through sperms
17. a. A.B T U E F G
R. S C D V W X
b. A.B C D
R. S T U V E F G W X
c. Robertsonian translocation is a special type of translocation, in which translocation occur between two acrocentric chromosomes (Chromosomes with one long arm and one very short arm) and become a one meta centric chromosome (Chromosome with two equal arms)
Robertsonian translocation of above two chromosomes gives: B C D E F G . S T U V W X
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