Why is it important for determining the function of a membrane protein to know i

Question

Why is it important for determining the function of a membrane protein to know if it spans the bilayer or appears only on one face of the membrane? As part of your answer give three example proteins and their functions. the protein Mop F poor in is embedded in the cell membrane and serves as a pore through the membrane. Structural analysis of the protein shown that the outside of the protein has a band of hydrophobic residues that is 27A tall and interacts directly with the nonpolar membrane (Panel et al Bio chime 1998: 80: 543-51). the upper and lower bounds of the band are defined by phenylalanine residues. the following shape represents a side view of the protein that is 40A tall. Draw the lipid bilayer on the shape below and indicate the location of the phenylalanine residues.

Explanation / Answer

1. The transmembrane proteins span across the lipid bilayer and therefore function as channels or active transport molecules to convey other molecules across the membrane .An example of transmembrane protein is cell surface receptors .These function by binding signal molecules in the extracellular space and produce various intracellular signals on the interior of the membrane.Another example of transmembrane proteins is voltage gated ion channels that provides the outlet for the diffusion of the substrate.

Proteins that are present only on one side of the membrane are either associated with lipids or protein moeity of the membrane.Examples of such poteins are enzymes such as cyclooxygenase and carnitine O- palmitoyltansferase.Proteins involved in intracellular signalling are bound to the cytosolic half of the plasma membrane.

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