Suppose that various members of a family spanning four generations have a mutant

Question

Suppose that various members of a family spanning four generations have a mutant phenotype that is very rare in the general population. The affected individuals are shown in the pedigree below.

Which is the anwer?

2 3 4 5 6 O 2 3 4 5 6 7 8 What is the most likely mode of inheritance for this rare phenotype? "Autosomal dominant and sex-limited to males, because the mutant allele can be inherited from an unaffected mother" "Autosomal recessive and sex-limited to males, because unaffected parents only have affected sons" "X-linked dominant, because affected males pass the sex-linked dominant mutant allele to their children" "X-linked recessive, because affected sons inherit the sex-linked mutation from their unaffected mothers" "Y-linked, because the rare phenotype is only found in males and affected fathers pass the mutant allele to their sons in every generation"

Explanation / Answer

Autosomal dominant and sex limited to males because the mutant allele can be inherited from an unaffected mother.

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