11. Which of the following is the least abundant isotype in human serum? a. IgA

Question

11. Which of the following is the least abundant isotype in human serum? a. IgA b. IgD c. IgE d. IgG e. IgM

12. Which of the following plays a role in rag weed allergies and allergies to bee venom? a. IgA b. IgD c. IgE d. IgG e. IgM

13. Which of the following is the first Ig produced in an immune response and can be detected in serum? a. IgA b. IgD c. IgE d. IgG e. IgM

14. Which of the following is the major Ig detected in saliva, breast milk, and tears? a. IgA b. IgD c. IgE d. IgG e. IgM

15. Plays a primary role in protecting against pathogens that may invade the body through the gut or respiratory mucosa? a. IgA b. IgD c. IgE d. IgG e. IgM

Explanation / Answer

Answer :

11. Least abundent antibody : IgE

Explanation : It is monomer and found in Lowest concentration. IgE plays an important role in allergic reactions by producing histamines.

12. Allergic antibody : IgE

13. First Ig produced in an immune response  : IgM

Explanation : IgM cccounts for 5-10% of the total serum immunoglobulins.It is a pentamer with the valency number 10.Each pentamer contains an extra additional Fc- linked polypeptide called the J chain.It is the first antibody class produced in a primary response to an antigen and it is also the first antibody to be synthesized by the neonate.

14. Major Ig detected in saliva, breast milk, and tears : IgA

Explanation : IgA constitutes 10 – 15% of the total immunoglobulins in the serum.It is a dimer, also contains J chain and a polypeptide chain called secretory component.It is the predominent antibody in the external secretions such as breast milk, saliva, tears, colostrum and mucus of the bronchial, genitourinary and digestive tracts. Passes from mother to a newborn through lactation.

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