Bookmark FGF2 can bind to both FGFR1c and to heparan sulfate proteoglycans (HSPG

Question

Bookmark FGF2 can bind to both FGFR1c and to heparan sulfate proteoglycans (HSPGs) simultaneously. The bi nding of FGF2 to FGFR1c has a K D = 10 nM, a nd the binding of FGF2 to HSPGs has a K D = 2 00 nM. The forward binding rate constant (k f ) for binding of FGF2 to either FGFR1c or HSPG is the same and is equal to 1 x 10 6 M - 1 min - 1 whereas the k f for binding of FGF2 to both FGFR1c and HSPG simultaneously is equal to 2 x 10 6 M - 1 min - 1 . Based on this information what might the K D for the simultaneous binding of FGF2 to FGFR1c and HSPG be? Explain your answer.

Explanation / Answer

FGF2 to FGFR1c KD = 10 nm

FGF2 to HSPGs   KD = 200 nm

kf for binding of FGF2 = 1 x 10 6 M - 1 min -1

kf for binding of FGF2 to both FGFR1c and HSPG = 2 x 106 M - 1min-1

KD value is low means that affinity between them is more in FGF2 - FGFR1c

forward binding of FGF2 to FGFR1c and HSPG means that FGF2 - FGFR1c - HSPG complex is formed

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