select and insert the most appropriate terms into the blanks in the sentences be
ID: 162471 • Letter: S
Question
select and insert the most appropriate terms into the blanks in the sentences below. There are about 20 different types of collagen proteins. These result in distinctly different qualities of connective tissue that can be used to perform different functions in different connective tissue locations. For example, collagens can be used to make porous nets in basement membranes surrounding capillary wall cells and other epithelial tissues, or used to make rope-like _________ and ligaments. The most common defect in osteogenesis imperfecta (OI) results from a mutation In the ___________ gene that leads to a prematurely stop in the process of ________. This results in a truncated protein that is ________. Because humans are diploid for all _________ chromosomes, we have at least __________ copies of every gene. The most serious bone breakage occurs when ________ of the _______ gene is/are defective. This is seen in ________ OI. Since the presence of a normal collagen gene cannot compensate for the loss of working protein from a defective gene we describe OI mutations as being _________. A tendency to exhibit _________ and loose joints is seen among children with __________ OI, while the most serious forms of OI result in death shortly after_________ doe to the extreme fragility of bones in the _________.Explanation / Answer
1. Collagens can be used to make porous membranes surrounding capillary wall cells and other epithelial tissues or used to make rope like membranes and ligaments.
2. The most common defect in osteogenesis imperfecta results from a mutation in the collagen I gene that leads to a prematurely stop in the process translation. This results in a truncated protein that is non functional.
3. Humans are diploid for all autosomal chromosomes, we have at least two copies of every gene. The most serious bone breakage occurs when one copy of the functional gene is defective. This is seen in type I OI. Since the presence of a normal collgen gene cannot compensate for the loss working protein from a defective gene we describe OI mutations as being dominant.
4. A tendency to exhibit and loose joints spinal curvature is seen among children with type II OI, while the most serious forms of OI result in death shortly after birth due to extreme fragility of bones in the chest
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