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Only the core promoter is involved in regulating transcription for most genes. T

ID: 162349 • Letter: O

Question

Only the core promoter is involved in regulating transcription for most genes. The promoter-proximal elements lie far from the coding sequence, but the core promoter lies close to the coding sequence. Core promoters can be removed from their locations and their orientation can be swapped, and they will still perform the same job in regulating transcription. This is not true for promoter-proximal regions. The core promoter is the site for binding of proteins required for transcribing all genes, such as TATA-binding protein and RNA polymerase, but the promoter-proximal elements are unique to sets of genes that are regulated together.

Explanation / Answer

The fourth option is correct, i.e., the core promoter is the site for binding of protein required for transcribing all genes but the promoter proximal elements are unique to sets of genes that are regulated together.