You have made a collection of mutant fruit flies that are defective in various a
ID: 161928 • Letter: Y
Question
You have made a collection of mutant fruit flies that are defective in various aspects of DNA repair. You test each mutant for its hypersensitivity to three DNA-damaging agents: sunlight, nitrous acid (which causes deamination of cytosine), and formic acid (which causes depurination). The results are summarized in Table Q6-55, where a "yes" indicates that the mutant is more sensitive than a normal fly, and blanks indicate normal sensitivity. USE CHAPTER 6 KNOWLEDGE (think about the DNA repair mechanism) AND DATA ANALYSIS SKILL) Which mutant is most likely to be defective in the DNA repair polymerase? What aspect of repair is most likely to be affected in the other mutants?Explanation / Answer
A. Sun light sensitive mutants are most likely to be defective in the DNA repair polymerases. Generally, sun light radiation causes mutations. This effect is reversed by a set of DNA repair polymerases called light sensitive repair polymerases. This is called Direct reversal of Damage. DNA photolyases also play a crucial role in Sun light associated mutational reverse. Mutants like Dracula, Mole & Mr. Self Destruct show defective in the DNA repair polymerases which reverse the Sunlight mutational effect
B. In Marguerite, Faust & Mr. Self Destruct species there is a defect Base and nucleotide excession repairs. Because, they get mutated only in presence of Deaminating agents & Depurinating agents.
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