What are the effects of increasing L (the T/R ratio) or of decreasing c (the rat

Question

What are the effects of increasing L (the T/R ratio) or of decreasing c (the ratio of KR/KT) on the shape of binding curve as modeled by Monod-Wyman-Changeux according to the concerted model of allosteric enzymes?

Select one:

a. As L increases, the sigmoidal shape increases; as c decreases, the sigmoidal shape increases

b. As L increases, the sigmoidal shape decreases; as c decreases, the sigmoidal shape decreases

c. As L increases, the sigmoidal shape increases; as c decreases, the sigmoidal shape decreases

d. As L increases, the sigmoidal shape decreases; as c decreases, the sigmoidal shape increases

Explanation / Answer

Answer : The correct answer is A (As L increases, the sigmoidal shape increases; as c decreases, the sigmoidal shape increases). Sigmoid kinetic behavior generally reflects cooperative interactions between protein subunits. In other words, changes in the structure of one subunit are translated into structural changes in adjacent subunits, an effect mediated by noncovalent interactions at the interface between subunits.

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