People with a deficiency in the FoxP3 protein suffer from a broad spectrum autoi

Question

People with a deficiency in the FoxP3 protein suffer from a broad spectrum autoimmune disease called IPEX. Which statement below provides a mechanistic explanation of this disease?
a. These patients have a defect in central tolerance.
b. These patients have a deficiency in regulatory T cells.
c. These patients suffer from a defect in peripheral tolerance.
d. These patients suffer from a defect in negative selection of thymocytes.
e. Both b. and c. provide explanations.

** I know that IPEX is dealing with t-cells... depletion of regulatory t cells... but i am not sure if it will also cause a defect in peripheral tolerance as well??

Please Help! Thanks :)

Explanation / Answer

e. Both b. and c. provide explanations. These patients have a deficiency in regulatory T cells. These patients suffer from a defect in peripheral tolerance.

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