* What would you predict to occur in a knock-out mouse with a deletion in CD28?
ID: 15380 • Letter: #
Question
* What would you predict to occur in a knock-out mouse with a deletion in CD28?a. The mouse will exhibit immunodeficiency due to an inability to effectively activate T cells.
b. The mouse will be unable to produce B cells.
c. The mouse will not have any T cells.
d. Antigen presenting cells will be unable to process antigens.
** I know the CD28 cells signals are required to protect T cells from apoptosis mediated by the death receptor Fas... so the answer would either be a or d right?
Please Help :) Thanks!
Explanation / Answer
A
-because the "Cluster of Differentiation" 28 is one of the molecules expressed on T cells. It provides co-stimulatory signals, which are required for T cell activation. With out it, there won't really be any active T cells .
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