12. How does infection with Campylobacter jejuni lead to Guillain-Barré syndrome
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Question
12. How does infection with Campylobacter jejuni lead to Guillain-Barré syndrome? A. C. jejuni produces an enterotoxin that can pass into the bloodstream. The enterotoxin can bind to nerve cells and form pores, which leads to death of nerve cells. B. C. jejuni invades epithelial cells and passes into the bloodstream. C. jejuni cross the blood-brain barrier and invades nerve cells. C. jejuni trigger apoptosis in the nerve cells leading to cell death. C. C. jejuni produces lipooligosaccharide (LOS) on its surface that are similar to structures produced on the surface of nerve cells. The immune system produces antibodies to LOS which also lead to targeting and destruction of nerve cells
12. How does infection with Campylobacter jejuni lead to Guillain-Barré syndrome? A. C. jejuni produces an enterotoxin that can pass into the bloodstream. The enterotoxin can bind to nerve cells and form pores, which leads to death of nerve cells. B. C. jejuni invades epithelial cells and passes into the bloodstream. C. jejuni cross the blood-brain barrier and invades nerve cells. C. jejuni trigger apoptosis in the nerve cells leading to cell death. C. C. jejuni produces lipooligosaccharide (LOS) on its surface that are similar to structures produced on the surface of nerve cells. The immune system produces antibodies to LOS which also lead to targeting and destruction of nerve cells
12. How does infection with Campylobacter jejuni lead to Guillain-Barré syndrome? A. C. jejuni produces an enterotoxin that can pass into the bloodstream. The enterotoxin can bind to nerve cells and form pores, which leads to death of nerve cells. B. C. jejuni invades epithelial cells and passes into the bloodstream. C. jejuni cross the blood-brain barrier and invades nerve cells. C. jejuni trigger apoptosis in the nerve cells leading to cell death. C. C. jejuni produces lipooligosaccharide (LOS) on its surface that are similar to structures produced on the surface of nerve cells. The immune system produces antibodies to LOS which also lead to targeting and destruction of nerve cells
Explanation / Answer
How does infection with Campylobacter jejuni lead to Guillain-Barré syndrome?
> C. jejuni produces lipooligosaccharide (LOS) on its surface that are similar to structures produced on the surface of nerve cells. The immune system produces antibodies to LOS which also lead to targeting and destruction of nerve cells.
Guillain-Barré syndrome (GBS) is an acute, immune-mediated, postinfection disorder influence the peripheral nervous system and is strongly linked with Campylobacter jejuni gastrointestinal (GI) infection . Articulation of ganglioside-like impression in the outer core lipooligosaccharide (LOS) and progress of an immune reaction in the host that cross-reacts with ganglioside-rich targets in the peripheral nerve are observe to be involved in the pathogenesis of Campylobacter-induced GBS .
Anti-GD1a antibodies are linked with the axonal (acute motor axonal neuropathy [AMAN]) to form GBS . anti-GM1 antibodies are notice in both AMAN and demyelinating (acute inflammatory demyelinating polyneuropathy [AIDP]) forms . Both AIDP and AMAN are linked with C. jejuni infection . patients with GBS following Campylobacter infection may be more likely to have axonal neuropathy.
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