The scheme illustrates the biosynthetic pathway for the formation of prostacycli

Question

The scheme illustrates the biosynthetic pathway for the formation of prostacyclin and thromboxane A2 (prostanoids involved in vasodilation and vasoconstriction mechanisms). diacyl gtycerol phospholpids arachidonic acid PGH, sywhase prostaglandin G Many drug discovery efforts to identify new therapeutics for asthma (chronic obstructed lung disease) focus on vasodilation and vasoconstriction mechanisms SHPETE synthase vasodilation a) Propose a druggable unstream taraet that could have a favorable therapeutic effect on asthma. (Explain) b) Propose a druggable downstream target that could have a favorable therapeutic effect on asthma. (Explain) c) Which target would likely lead to the development of a drug with a better safety profile and fewer side effects. (Explain)

Explanation / Answer

a) A decline in the upstream production of various type of IgE type of antibodies can lead to the minimal rate of the chances of the asthma in the suffering patient. recent studies showed that several type of allergic reaction mediated by the production of the antibodies can cause the chances of the asthma in the patients.

b) the various types of studies which are associated with the polymorphisms of the genes which are susceptible help in revealing the downstream regulation of the asthma. The various downstreams receptors pose major effects on the polymorphisms of the various steroids and hence regulate the downstram target for the asthama.

c) The upstream taget would provide the better result bacause no use of receptors is associated and the generation of the various types of antibodies in limited amount can be easily controlled by the upstream target process.

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