Tissue hypoxia will cause the oxyhemoglobin curve to shift to the left or right?

Question

Tissue hypoxia will cause the oxyhemoglobin curve to shift to the left or right?

Low blood 100 a90 " 80 70 6 60 Normal blood H High blood Pco2 5 30 E 20 10 0 10 20 30 40 50 60 70 80 90 Po2 (mmHg) Effect of Pco2 on affinity of hemoglobin for oxyger igure 23-21b Principles of Anatomy and Physiology, 11ie Low temperature 100 L (20° C,68° F) O 90 E 80 GJ Normal blooc temperature (37° C, 98.6° F 70 50 o 40 High temperature (43° C, 110° F) 3 20 10 0 10 20 30 40 50 60 70 80 90100 Po2 (mmHg) Figure 23-22 Principles of Anatomy and Physiology, 11/e

Explanation / Answer

Tissue hypoxia will lead to increase in Carbon dioxide(CO2) concentration in the tissue and in blood.

From the first graph of oxygen-hemoglobin dissociation curve we can easily interpret that as CO2 concentration increases, the Oxygen-hemoglobin dissociation curve shifts to the right.

Therefore during hypoxia, the graph will shift to the right.

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