Order the following steps of clonal selection and expansion from the first step

Question

Order the following steps of clonal selection and expansion from the first step to last step. Rank the options below That lymphocyte undergoes mitotic division, forming a large population of cells with the same specificity. A specific lymphocyte is stimulated by its specific antigen. Lymphocytes migrate to secondary lymphoid tissues Bone marrow stem cells differentiate into lymphocytes. 8 cells mature in the bone marow and T cells mature in the thymus, meaning they build a unique antigen receptor based on genetic recombinations.

Explanation / Answer

Clonal selection involves recognition, selection, variance and clonal expansion of selected type of cells followed by effector action and memory.

The steps include:

1. Bone marrow stem cells differentiate in to lymphocytes.

2. B cells mature in the bone marrow and T cells in the thymus, meaning they build a unique antigen receptor based on genetic recombination.

3. A specific lymphocyte is stimulated by its specific antigen.

4. That lymphocyte undergoes mitotic division, forming a large population of cells with the same specificity.

5. Lymphocytes migrate to secondary lymphoid tissues.

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