A drug tested on laboratory mice (20 g) is approved for the use in human subject

Question

A drug tested on laboratory mice (20 g) is approved for the use in human subjects (50 kg). The optimal administered dosage in mice is found to be 1 mg/kg body weight. What would you estimate to be the optimal administered dosage appropriate to a human subject? Remember: the effective concentration at the drug's target action depends on the amount of drug consumed, the rate of absorption, the rate of metabloc conversion to an inactive form, and the rate of excretion with rates of metabolism and excretion being the rate-determining factor.

Explanation / Answer

The optimal administered dosage in mide was found as 1 mg/kg body weight, so for human also the optimal administered dosage will be 1 mg/kg body weight. If the body weight of human is 50 kg, then the optimal dose will be 50 mg.

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